Maintenance of telomere capping is absolutely essential to the survival of eukaryotic cells.Telomere capping proteins, such as Cdc13 and POT1, are essential for the viability of budding yeast and mammalian cells, respectively.Here we identify, for the first time, three genetic modifications that allow budding yeast cells to survive without telomere
Abstract The European Health Data Space (EHDS) aims to make the primary use of health data for healthcare provision more continuous, effective, and (cost) efficient.Moreover, it pursues to facilitate the secondary use of health data for purposes such as research, innovation, and policy making.In the context of secondary use, the EHDS legislative pr
Movements in animals arise through concerted action of neurons and skeletal muscle.General anaesthetics prevent movement and cause loss of consciousness by blocking neural function.Anaesthetics of the amino amide-class are thought to act by blockade of voltage-gated sodium channels.In fish, the commonly used anaesthetic tricaine methanesulphonate,
Image segmentation is critical and challenging in computer vision and medical image analysis.Despite decades of research, existing segmentation algorithms are still subject to typical segmentation problems, such as over-segmentation, under-segmentation, and non-closed and spurious edges.In this paper, taking the carpal bones from hand X-ray images